Zhang, C., Yang, Y., Qi, T., Zhang, Y., Hou, L., Wei, J., Yang, J., Shi, L., Ong SG., Wang, H., Wang, H., Yu, B., & Wang, Y. Prediction of base editor off-targets by deep learning. Nature Communications. PMID: 37660097
Srivastava, S., Gajwani, P., Jousma, J., Miyamoto, H., Kwon, Y., Jana, A., Toth, P. T., Yan, G., Ong SG., & Rehman, J. Nuclear translocation of mitochondrial dehydrogenases as an adaptive cardioprotective mechanism. Nature Communications. PMID: 37468519
Nukala, S. B., Jousma, J., Yan, G., Han, Z., Kwon, Y., Cho, Y., Liu, C., Gagnon, K., Pinho, S., Rehman, J., Shao, N. Y., Ong, S. B., Lee, W. H., & Ong SG. Modulation of lncRNA links endothelial glycocalyx to vascular dysfunction of tyrosine kinase inhibitor. Cardiovascular Research. PMID: 37267414
Yuan, Y., Shi, Z., Xiong, S., Hu, R., Song, Q., Song, Z., Ong SG., & Jiang, Y. Differential roles of insulin receptor in adipocyte progenitor cells in mice. Molecular and Cellular Endocrinology. PMID: 37244600
Wu, R., Park, J., Qian, Y., Shi, Z., Hu, R., Yuan, Y., Xiong, S., Wang, Z., Yan, G., Ong SG., Song, Q., Song, Z., Mahmoud, A. M., Xu, P., He, C., Arpke, R. W., Kyba, M., Shu, G., Jiang, Q., & Jiang, Y. Genetically prolonged beige fat in male mice confers long-lasting metabolic health. Nature Communications. PMID: 37169793
Li, Y., Chinda, K., Xiang, Y., Zhou, H., Xu, D., Ong SG., & Ong, S. B. Harnessing mitochondrial transplantation to sustain cardiac function: Another step forward. Molecular Therapy: The Journal of the American Society of Gene Therapy. PMID: 37141857
Liu, C. W., Le, H. H. T., Denaro, P., Dai, Z., Shao, N. Y., Ong SG, & Lee, W. H. E-cigarettes Induce Dysregulation of Autophagy Leading to Endothelial Dysfunction in Pulmonary Arterial Hypertension. Stem Cells. PMID: 36640125
Chang, X., Ismail, N. I., Rahman, A., Xu, D., Chan, R. W. Y., Ong SG., & Ong, S. B. Long COVID-19 and the Heart: Is Cardiac Mitochondria the Missing Link?. Antioxidants & Redox Signaling. PMID: 36053670
2022
Wang, S., Tao, C., Mao, H., Hou, L., Wang, Y., Qi, T., Yang, Y., Ong SG., Hu, S., Chai, R., & Wang, Y. Identification of SaCas9 orthologs containing a conserved serine residue that determines simple NNGG PAM recognition. PLoS Biology. PMID: 36449487
Jousma, J., Han, Z., Yan, G., Nukala, S. B., Kwon, Y., Thi Le, H. H., Li, Y., Ong, S. B., Lee, W. H., & Ong SG. Alteration of the N6-methyladenosine epitranscriptomic profile in synthetic phthalate-treated human induced pluripotent stem cell-derived endothelial cells. Epigenomics. PMID: 36314267
Ismail, N. I., Michel, N. A., Katwadi, K., Lim, M. M., Chan, T. K., Rahman, A., Xu, D., Ong SG., Hausenloy, D. J., & Ong, S. B. Ischemic Preconditioning and Postconditioning Protect the Heart by Preserving the Mitochondrial Network. BioMed Research International. PMID: 36203484
Gara, E., Ong SG., Winkler, J., Zlabinger, K., Lukovic, D., Merkely, B., Emmert, M. Y., Wolint, P., Hoerstrup, S. P., Gyöngyösi, M., Wu, J. C., & Pavo, N. Cell-Based HIF1α Gene Therapy Reduces Myocardial Scar and Enhances Angiopoietic Proteome, Transcriptomic and miRNA Expression in Experimental Chronic Left Ventricular Dysfunction. Frontiers in Bioengineering and Biotechnology. PMID: 35646882
Ly, O. T., Chen, H., Brown, G. E., Hong, L., Wang, X., Han, Y. D., Pavel, M. A., Sridhar, A., Maienschein-Cline, M., Chalazan, B., Ong SG., Abdelhady, K., Massad, M., Rizkallah, L. E., Rehman, J., Khetani, S. R., & Darbar, D. Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model. JCI Insight. PMID: 35393944
Nukala, S. B., Jousma, J., Cho, Y., Lee, W. H., & Ong SG. Long non-coding RNAs and microRNAs as crucial regulators in cardio-oncology. Cell & Bioscience. PMID: 35246252
2021
Hu, Z., Zhang, C., Wang, D., Gao, S., Ong SG., Wang, Y., & Zheng, W. V.. A Highly Sensitive GFP Activation Assay for Detection of DNA Cleavage in Cells. Frontiers in Cell and Developmental Biology. PMID: 34869366
Hong, L., Zhang, M., Ly, O. T., Chen, H., Sridhar, A., Lambers, E., Chalazan, B., Youn, S. W., Maienschein-Cline, M., Feferman, L., Ong SG., Wu, J. C., Rehman, J., & Darbar, D. Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation. Stem Cell Reports. PMID: 34019817
Chang, A. C. Y., Pardon, G., Chang, A. C. H., Wu, H., Ong SG., Eguchi, A., Ancel, S., Holbrook, C., Ramunas, J., Ribeiro, A. J. S., LaGory, E. L., Wang, H., Koleckar, K., Giaccia, A., Mack, D. L., Childers, M. K., Denning, C., Day, J. W., Wu, J. C., Pruitt, B. L., … Blau, H. M. Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes. Stem Cell Reports. PMID: 34019816
Park, J., Shin, S., Liu, L., Jahan, I., Ong SG., Xu, P., Berry, D. C., & Jiang, Y. Progenitor-like characteristics in a subgroup of UCP1+ cells within white adipose tissue. Developmental Cell. PMID: 33711247
Jang, H. R., Cho, H. J., Zhou, Y., Shao, N. Y., Lee, K., Le, H. H. T., Jeon, J., Lee, J. E., Huh, W., Ong SG., Lee, W. H., & Kim, Y. G. Modeling Uremic Vasculopathy With Induced Pluripotent Stem Cell-Derived Endothelial Cells as a Drug Screening System. Frontiers in cell and developmental biology. PMID: 33511129
2020
Kwon, Y., Nukala, S. B., Srivastava, S., Miyamoto, H., Ismail, N. I., Jousma, J., Rehman, J., Ong, S. B., Lee, W. H., & Ong SG. Detection of viral RNA fragments in human iPSC cardiomyocytes following treatment with extracellular vesicles from SARS-CoV-2 coding sequence overexpressing lung epithelial cells. Stem Cell Research & Therapy. PMID: 33256833
Prakash, A., Crespo-Avilan, G. E., Hernandez-Resendiz, S., Ong SG., & Hausenloy, D. J. Extracellular vesicles - mediating and delivering cardioprotection in acute myocardial infarction and heart failure. Conditioning Medicine. PMID: 34296067
Kalkhoran, S. B., Hernandez-Resendiz, S., Ong SG., Ramachandra, C. J. A., & Hausenloy, D. J. Mitochondrial shaping proteins as novel treatment targets for cardiomyopathies. Conditioning Medicine. PMID: 33134886
Pearl D., Katsumura S., Amiri M., Tabatabaei, N. Zhang, X., Vinette, V. Pang, X. Beug, S. T. Kim, S. H. Jones, L. M. Robichaud, N. Ong SG., Jia J. J., Ali H., Tremblay M. L., Jaramillo, M., Alain, T., Morita, M., Sonenberg, N., & Tahmasebi, S. 4E-BP-Dependent Translational Control of Irf8 Mediates Adipose Tissue Macrophage Inflammatory Response. Journal of immunology. PMID: 32213561
Tian L, Oikonomopoulos A, Liu C, Kitani T, Shrestha R, Chen CL, Ong SG, Smeets M, Karakikes I, Sayed N, Wu JC. Molecular signatures of beneficial class effects of statins on human induced pluripotent stem cell-derived cardiomyocytes. Circulation. PMID: 32250699.
Hu Z, Wang S, Zhang C, Gao N, Li M, Wang D, Wang D, Liu D, Liu H, Ong SG, Wang H, Wang Y. A compact Cas9 ortholog from Staphylococcus Auricularis (SauriCas9) expands the DNA targeting scope. PloS Biol. PMID: 32226015.
Pearl D, Katsumura S, Amiri M, Tabatabaei N, Zhang X, Vinette V, Pang X, Beug ST, Kim SH, Jones LM, Robichaud N, Ong SG, Jia JJ, Ali H, Tremblay ML, Jaramillo M, Alain T, Morita M, Sonenberg N, Tahmasebi S. 4E-BP-dependent translation control of Irf8 mediates adipose tissue macrophage inflammatory response. J Immunol. PMID: 32213561.
2019
Lee WH*, Ong SG*, Zhou Y, Tian L, Bae HR, Whitlatch A, Mohammadi L, Guo H, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC. Modeling cardiovascular risks of e-cigarettes with human induced pluripotent stem cell-derived endothelial cells. J Am Coll Cardiol. PMID: 31146818. *Co-first authors
Wang B, Wang Z, Wang D, Zhang B, Ong SG, Li M, Yu W, Wang Y. krCRISPR: an easy an efficient strategy for generating conditional knockout of essential genes in cells. J Biol Eng. PMID: 31049076.
Kitani T, Ong SG, Lam CK, Rhee JW, Zhang JZ, Oikonomopoulos A, Ma N, Tian L, Lee J, Telli ML, Witteles RM, Sharma A, Sayed N, Wu JC. Human induced pluripotent stem cell model of trastuzumab-induced cardiac dysfunction in breast cancer patients. Circulation. PMID: 30866650.
Ong SB, Lee WH, Shao NY, Ismail NI, Katwadi K, Lim MM, Kwek XY, Michel NA, Li J, Newson J, Tahmasebi S, Rehman J, Kodo K, Jang HR, Ong SG. Calpain inhibition restores autophagy and prevents mitochondrial fragmentation in a human iPSC model of diabetic endotheliopathy. Stem Cell Reports. PMID: 30799273.
2018
Ong SG, Lee WH, Zhou Y, Wu JC. Mining exosomal microRNAs from human-induced pluripotent stem cells-derived cardiomyocytes for cardiac regeneration. Methods Mol Biol. PMID: 29435928.
Ong SB, Katwadi K, Kwek XY, Ismail NI, Chinda K, Ong SG, Hausenloy DJ. Non-coding RNAs as therapeutic targets for preventing myocardial ischemia-reperfusion injury. Expert Opin Ther Targets. PMID: 29417868.
2017
Zhao MT, Chen H, Liu Q, Shao NY, Sayed N, Wo HT, Zhang JZ, Ong SG, Liu C, Kim Y, Yang H, Chour T, Ma H, Gutierrez NM, Karakikes I, Mitalipov S, Snyder MP, Wu JC. Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. Proc Natl Acad Sci U S A. PMID: 29203658.
Kodo K, Shibata S, Miyagawa-Tomita S, Ong SG, Takahashi H, Kume T, Okano H, Matsuoka R, Yamagishi H. Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development. Sci Rep. PMID: 28754980.
Lee WH, Chen WY, Shao NY, Xiao D, Qin X, Baker N, Bae HR, Wei TT, Wang Y, Shukla P, Wu H, Kodo K, Ong SG*, Wu JC*. Comparison of Non-Coding RNAs in Exosomes and Functional Efficacy of Human Embryonic Stem Cell- versus Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells. PMID: 28710827. *Co-senior authors
Reddy S, Hu DQ, Zhao M, Blay E Jr, Sandeep N, Ong SG, Jung G, Kooiker KB, Coronado M, Fajardo G, Bernstein D. miR-21 is associated with fibrosis and right ventricular failure. JCI Insight. PMID: 28469078.
Ong SB, Kalkhoran SB, Hernández-Reséndiz S, Samangouei P, Ong SG, Hausenloy DJ. Mitochondrial-shaping proteins in cardiac health and disease - the long and the short of It! Cardiovasc Drugs Ther. PMID: 28190190.
2016
Chang AC, Ong SG, LaGory EL, Kraft PE, Giaccia AJ, Wu JC, Blau HM. Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. PMID: 27799523.
Kodo K*, Ong SG*, Jahanbani F, Termglinchan V, Hirono K, InanlooRahatloo K, Ebert AD, Shukla P, Abilez OJ, Churko JM, Karakikes I, Jung G, Ichida F, Wu SM, Snyder MP, Bernstein D, Wu JC. iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy. Nat Cell Biol. PMID: 27642787. *Co-first authors
Hnatiuk AP*, Ong SG*, Olea FD, Locatelli P, Riegler J, Lee WH, Jen CH, De Lorenzi A, Giménez CS, Laguens R, Wu JC, Crottogini A. Allogeneic mesenchymal stromal cells overexpressing mutant human hypoxia-inducible factor 1-α (HIF1-α) in an ovine model of acute myocardial infarction. J Am Heart Assoc. PMID: 27385426. *Co-first authors
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nat Med. PMID: 27089514.
Riegler J, Ebert A, Qin X, Shen Q, Wang M, Ameen M, Kodo K, Ong SG, Lee WH, Lee G, Neofytou E, Gold JD, Connolly AJ, Wu JC. Comparison of magnetic resonance imaging and serum biomarkers for detection of human pluripotent stem cell-derived teratomas. Stem Cell Reports. PMID: 26777057.
2015
Mukherjee UA, Ong SB, Ong SG, Hausenloy DJ. Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection. Pharmacol Ther. PMID: 26481155.
Ong SG, Huber BC, Lee WH, Kodo K, Ebert AD, Ma Y, Nguyen PK, Diecke S, Chen WY, Wu JC. Microfluidic single-cell analysis of transplanted human induced pluripotent stem cell-derived cardiomyocytes after acute myocardial infarction. Circulation. PMID: 26304668.
Nguyen PK, Lee WH, Li YF, Hong WX, Hu S, Chan C, Liang G, Nguyen I, Ong SG, Churko J, Wang J, Altman RB, Fleischmann D, Wu JC. Assessment of the radiation effects of cardiac CT angiography using protein and genetic biomarkers. JACC Cardiovasc Imaging. PMID: 26210695.
Ong SG, Wu JC. Exosomes as potential alternatives to stem cell therapy in mediating cardiac regeneration. Circ Res. PMID: 26089361.
Ong SG, Lee WH, Kodo K, Wu JC. MicroRNA-mediated regulation of differentiation and trans-differentiation in stem cells. Adv Drug Deliv Rev. PMID: 25887992.
Lee WH, Nguyen P, Hu S, Liang G, Ong SG, Han L, Sanchez-Freire V, Lee AS, Vasanawala M, Segall G, Wu JC. Variable activation of the DNA damage response pathways in patients undergoing single-photon emission computed tomography myocardial perfusion imaging. Circ Cardiovasc Imaging. PMID: 25609688.
Gu M, Mordwinkin NM, Kooreman NG, Lee J, Wu H, Hu S, Churko JM, Diecke S, Burridge PW, He C, Barron FE, Ong SG, Gold JD, Wu JC. Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism. Eur Heart J. PMID: 25368203.
2014
Ong SG, Lee WH, Huang M, Dey D, Kodo K, Sanchez-Freire V, Gold JD, Wu JC. Cross talk of combined gene and cell therapy in ischemic heart disease: role of exosomal microRNA transfer. Circulation. PMID: 25200057.
Sanchez-Freire V, Lee AS, Hu S, Abilez OJ, Liang P, Lan F, Huber BC, Ong SG, Hong WX, Huang M, Wu JC. Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells. J Am Coll Cardiol. PMID: 25082575.
Ong SG, Lee WH, Theodorou L, Kodo K, Lim SY, Shukla DH, Briston T, Kiriakidis S, Ashcroft M, Davidson SM, Maxwell PH, Yellon DM, Hausenloy DJ. HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore. Cardiovasc Res. PMID: 25063991.
2013
Ong SG, Wu JC. Cortical bone-derived stem cells: a novel class of cells for myocardial protection. Circ Res. PMID: 23948579.
Keeney M*, Ong SG*, Padilla A, Yao Z, Goodman S, Wu JC, Yang F. Development of poly(β-amino ester)-based biodegradable nanoparticles for nonviral delivery of minicircle DNA. ACS Nano. PMID: 23837668. *Co-first authors
2012
Ong SG, Hausenloy DJ. Hypoxia-inducible factor as a therapeutic target for cardioprotection. Pharmacol Ther. PMID: 22800800.
2010
Smith CC, Dixon RA, Wynne AM, Theodorou L, Ong SG, Subrayan S, Davidson SM, Hausenloy DJ, Yellon DM. Leptin-induced cardioprotection involves JAK/STAT signaling that may be linked to the mitochondrial permeability transition pore. Am J Physiol Heart Circ Physiol. PMID: 20656889.
Hausenloy DJ, Lim SY, Ong SG, Davidson SM, Yellon DM. Mitochondrial cyclophilin-D as a critical mediator of ischaemic preconditioning. Cardiovasc Res. PMID: 20400621.