WHAT WE DO
The Ong Lab investigates a range of research topics, all of which center on deciphering the molecular mechanisms of cardiovascular disease and dysfunction and using this information to develop potential therapeutic strategies. Toward this end, we use human induced pluripotent stem cells as a platform along with mouse models to study the pathogenesis of cardiovascular diseases through cellular, genetic, and biochemical approaches. We are particularly interested in cardiometabolic diseases with a focus on both mitochondrial and RNA biology.
We are also interested in investigating the biology of myocardial infarction, including developing cardioprotective strategies involving the mitochondrial permeability transition pore, stem cells for regenerative medicine, and exosomes in mediating myocardial repair.
We are also interested in investigating the biology of myocardial infarction, including developing cardioprotective strategies involving the mitochondrial permeability transition pore, stem cells for regenerative medicine, and exosomes in mediating myocardial repair.
News
- (03/2020) - We received the NOA for 1st R01 grant from NHLBI which was scored at 4th percentile.
- (02/2020) - Sarath joined the Ong lab as a postdoc.
- (02/2019) - First manuscript from the Ong Lab using iPSCs to study diabetic endotheliopathy has been published in Stem Cell Reports.
- (12/2018) - Warm welcome to Shubhi, Jiajun, and Youjeong for joining the Ong Lab!! We are still actively recruiting two more postdocs.
- (08/2018) – The Ong Lab started its operation in the Department of Pharmacology and the Center for Stem Cell and Regenerative Medicine at UIC College of Medicine. We are currently seeking potential candidates for postdoctoral and research assistants positions.